Fibroblastic Disorders

Fibroblastic Reticular Cells: Organization

Pediatric Fibroblastic and Myofibroblastic Tumors

Spectrum of Fibroblastic and Myofibroblastic Tumors When one considers soft tissue tumors in pediatrics, tumors of vascular (29%), neurogenic (15%), and myogenic (striated muscle, 14%) origin occur more often than fibroblastic-myofibroblastic tumors (12%). The spectrum of fibroblastic/myofibroblastic tumors is quite divergent from both clinical and histopathologic viewpoints (Table 1). These tu...

Response of Fibroblastic Rheumatism to Infliximab

Onset is usually sudden with symmetrical articular involvement of both small and large joints, occurrence of solid skin nodules, and rapid progression. Treatment is generally unrewarding. Here we report a severe and disabling case of FR responding favorably to infliximab therapy. After 32 weeks of continuous treatment, skin lesions dramatically improved and arthropathy partially regressed.

Benign and Intermediate Fibroblastic/Myofibroblastic Lesions

Fibroblastic osteosarcoma in a lion (Panthera leo)

This report describes a case of spontaneous fibroblastic osteosarcoma in the humerus of a lion from a private park in Perugia, Italy. The tumor had an irregular, smooth, brown surface and a generally firm, rubbery consistence with gritty to hard areas interspersed. The mass was poorly vascularized with areas of necrosis at the periphery. The cut surface showed a multilobulated mass that had bre...